Abstract: Acne scarring is a common sequela of acne that causes facial disfigurement and psychological distress, severely impairing patients' quality of life. Treatment remains difficult, as conventional approaches are limited by trauma, insufficient deep tissue action, and unstable efficacy. Biologic therapies show clear benefits in regulating inflammation, inhibiting fibrosis, and promoting collagen remodeling. Novel delivery systems—including microneedles, nano-delivery systems, and hydrogels—can improve the stability, skin penetration, and local retention of bioactive agents to enhance therapeutic efficacy. This paper reviews the research progress of novel drug delivery systems combined with biologic therapies for acne scarring, to provide a reference for clinical practice.

Key words: acne scarring, microneedles, nano-delivery systems, hydrogels, biologic therapy