Abstract: Objective: To correlate autologous serum skin test (ASST) and some laboratory tests with clinical severity of chronic spontaneous urticaria (CSU). Methods: Clinical data of 136 patients with CSU were collected, and ASST, serum total IgE, plasma D-dimer, thyroid function and autoantibody detection were performed. Results: Out of the 136 patients, serum total IgE was elevated in 37 patients. ASST was positive in 54 (39.7%). The mean duration of CSU was significantly longer in the ASST-positive patients (45.27±65.67 months) than in ASST-negative patients (35.24±42.54 months) (P＜0.01). Plasma D-dimer was elevated in 49(36%), which was correlated with ？UAS (P＜0.01, r=0.469). Antithyroglobulin antibody was positive in 24 patients (17.6%) and antithyroperoxidase antibody was positive in 14 (10.6%). Twienty-five patients had thyroid dysfunction (9 of them were positive for ASST). Conclusion: Our study shows that the severity of CSU is correlated with ASST and plasma D-dimer level, but not serum total IgE.

Key words: chronic spontaneous urticaria, autologous serum skin test, plasma D-dimer