Abstract: Objective：To report a case of primary cutaneous mucormycosis caused by Syncephalastrum racemosum and review the related literature. Methods：A 67-year-old female presented with painful nodules and exudation on right ankle for 3 years. Smear and lesional tissues were taken for fungal culture and histopathologic examination. PCR (rDNA ITS sequence analysis) was performed to identify the species of the cultured fungi. Results：Microscopically demonstrated numerous hyphae. Numerous white cottony colonies grew on SDA culture medium. Microscopic examination of the H&E-stained tissue slides revealed a chronic granulomatous inflammation. In the tissue examined, clumps hyphae of various lengths were observed. The PAS and Silver stains also showed positive hyphae. The strain was identified as Syncephalastrum racemosum by ITS sequence analysis. The patient was improved with surgical intervention and oral itraconazole. Conclusions：The pathogen of this case is caused by Syncephalastrum racemosum. Itraconozole and surgical intervention is effective.

Key words: mucormycosis, Syncephalastrum racemosum