China Journal of Leprosy and Skin Diseases ›› 2016, Vol. 32 ›› Issue (12): 724-726.

Previous Articles     Next Articles

Lack of association between GLCCI1 variant and glucocorticoid sensitivity in Chinese patients with bullous diseases

DU Tiantian1,2, FU Xi’an1, SUN Yonghu1, YU Gongqi1, WANG Zhenzhen1, YANG Baoqi1, LU Xianmei1, LIU Hong1, ZHANG Furen1   

  1. l. Shandong Provincial Institute of Dermatology and Venerueology, Provincial Academy of Medical Science, Jinan 250022, China; 2. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, China
  • Online:2016-12-15 Published:2018-12-21
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

PDF (PC)

80

Like

Abstract: Objective: To investigate the association between GLCCI1 gene and GC sensitivity in Chinese patients with bullous diseases. Methods：A total of 187 subjects were divided into GC-sensitive group (control dose ≤60 mg, n=129) and GC-insensitive group (control dose ≥150 mg, n=58). Single SNP (rs37973) was genotyped with TaqMan SNP Genotyping Assay Kit on the GeneAmp 7900 Sequence Detection System using specific TaqMan probes. The statistical analysis was performed using logistic regression in PLINK. Results: We failed to detect rs37973 variation in the patients with GC-insensitive bullous diseases (P=0.7881, odds ratio=1.062). Conclusion: There is no association between GLCCI1 and glucocorticoids sensitivity in Chinese patients with bullous diseases.

Key words: GLCCI1, glucocorticoids, bullous diseases