Abstract: Objective：To detect the expression level of peroxiredoxin I (Prx I) and cytoplasmic linker associated protein 1 (CLASP1) in the lesions of symmetrical acrokeratoderma (SAK). Methods: The level of Prx I and CLASP1 mRNA in lesions and perilesional skin from 9 patients and normal skin from 9 healthy controls was detected by RT-PCR and the level of protein was detected by immunohistochemistry. Results: The expression level of Prx I and CLASP1 mRNA in lesions was (0.94±0.66) and (0.95±0.76), which was higher than those in perilesional skin (0.51±0.20 and 0.56±0.31) and normal skin (0.45±0.26 and 0.47±0.33). Positive cells of Prx I were in the stratum spinosum and basal layers predominantly in the skin lesions, while that of CLASP1 were in the stratum spinosum. The number and degree of positive cells of Prx I and CLASP1 in lesions were more than those in the perilesional and normal skin. Conclusion: Overexpression of Prx I and CLASP1 might be involved in the hyperproliferation and abnormal differentiation of epidermal keratinocytes in the lesions of SAK.

Key words: symmetrical acrokeratoderma, peroxiredoxin I, cytoplasmic linker associated protein