Abstract: Granulysin, a cytolytic and proinflammatory molecule which is produced by activated human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells plays a significant role in the development of multiple skin diseases such as Stevens-Johnson syndrome/toxic epidermal necrosis (SJS/TEN)，psoriasis, folliculitis, lichen planus and viral vesicles, etc. Especially granulysin is a key mediator for disseminating keratinocyte apoptosis in SJS/TEN. Studies on application of granulysin in skin disease including early diagnosis, illness monitoring and treatment was reviewed in the paper.

Key words: granulysin, toxic epidermal necrosis