Abstract: A 48-year-old female presented with hyperkeratotic papules on lower limbs for six months. Physical examination revealed multiple, symmetrically disseminated hyperkeratotic papules on the lower extremities. The size of the papules ranged from 1 to 5 mm in diameter. Biopsy revealed focal hyperkeratosis, atrophic epidermis and lymphocytic infiltration. The diagnosis of hyperkeratosis lenticularis perstans was made. The treatment with retinoid was partially effective.