China Journal of Leprosy and Skin Diseases ›› 2016, Vol. 32 ›› Issue (7): 391-393.

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Relationship between advanced oxidation protein products and lupus nephritis

XIE Zhen1, CHEN Yuanhan2, WANG Youwei1, LIU Yangying1, WAN Huiying1, ZHOU Min1   

  1. 1. Department of Dermatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital , Chengdu 610000, China; 2. Department of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
  • Online:2016-07-15 Published:2018-12-21
  • Contact: CHEN Yuanhan, E-mail: johnchen76@126.com

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Abstract: Objectives：To determine the relationship between advanced oxidation protein products (AOPP) and lupus nephritis (LN). Methods：The level of AOPP in 36 patients with lupus dermatitis (LD) complicated with LN and 56 LD patients without LN were detected and the relationship between AOPP and LN was analyzed. Results：The level of AOPP in LD accompanied with LN patients was (105.6±28.5)μmol/L, which was higher than that in the patients with LD but without LN (64.6±20.4 μmol/L). The level of ds-DNA and urine?protein in the patients with high level AOPP (>84.5μmol/L) was higher than those in the patients with low level of AOPP, and the level of eGFR and complement C3 was lower than those in the patients with low level of AOPP . In multivariable logistic regression model, AOPP level was an independent risk factor for lupus nephritis and the renal risk would increase by 24%, as every 10 μmol/L of AOPP was increased (95%CI 1.166-1.915). Conclusion：AOPP is associated with the onset of LN and may be a potential biomarker for LN.

Key words: advanced oxidation protein products, lupus nephritis, lupus dermatitis