China Journal of Leprosy and Skin Diseases ›› 2016, Vol. 32 ›› Issue (9): 527-529.

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Correlation of cutaneous manifestation with associated biochemical markers in patients with polycystic ovary syndrome

FENG Jinge1, WANG Wei2, MA Liang3, XING Jin1, SUN Ruifeng4, ZHU Wei4   

  1. 1. Department of Dermatology, FuXing Hospital of Capital Medical University, Beijing 100038,China 2. Department of Physiology, Capital Medical University, Beijing100069, China. 3.Department of Physical Examination, Primary and Middle School Health Care Institute of Xuanwu District, Beijing 100050,China 4 Department of Dermatology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Online:2016-09-15 Published:2018-12-14
  • Contact: ZHU Wei, E-mail：zhuwei@xwh.ccmu.edu.cn

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Abstract: Objective：To evaluate the relationship between serum total testosterone (TT), free androgen index (FAI) with polycystic ovary syndrome (PCOS). Methods：The levels of TT and FAI of 45 patients with polycystic ovary syndrome and 42 healthy controls were detected by chemiluminescence apparatus. The hirsutism, severity?of?acne and androgenic alopecia were assessed by Ferriman-Gallwey (M-FG) score, Global Acne Grading System (GAGS) and Ludwig classication method respectively. Results：The sensitivity and specificity of FAI for hirsutism, acne and androgenic alopecia were 80.2%, 68.9% and 60.3%, and 41.5%, 49.2% and 36.8%, respectively. The sensitivity and specificity of TT were 20.6%, 21.4% and 29.8%, and 46.5%, 44.8% and 58.3% respectively. Conclusion：The hirsutism, severity?of?acne and androgenic alopecia were closely related with FAI, but the correlation with TT was low. So FAI can be used as a screening biochemical marker in the diagnosis of PCOS.

Key words: polycystic ovary syndrome, hyperandrogenism, free androgen index, total testosterone