Abstract:

Objective: To detect the expression of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in the plasma of the patients with psoriasis vulgaris (PV). Methods: The plasma levels of BDNF and VEGF were measured by ELISA in the 42 patients (23 patients in active stage and 19 in stable stage) and 16 healthy controls. Results: The plasma levels of BDNF and VEGF were higher in the patients with PV than in healthy controls (P<0.01). The levels of BDNF and VEGF in the patients in active stage were higher than in the patients in stable stage (P<0.01). There was a positive correlation between the plasma level of BDNF and PASI (P<0.01) and there was no correlation between plasma level of VEGF and PASI (P>0.05). Conclusion: BDNF and VEGF may be involved in the pathogenesis of PV

Key words: psoriasis vulgaris')">

psoriasis vulgaris, brain-derived neurotropic factor, vascular endothelial growth factor