Abstract:

Objective: To determine the effects of desloratadine citrate disodium on the edema degree of ears and the cytokine expression of Th1/Th2 cell in murine allergic contact dermatitis (ACD). Methods: The animal model of allergic contact dermatitis was established and then the inhibition effect of desloratadine citrate disodium in different doses (1 mg/kg, 2 mg/kg, 3 mg/kg and 4 mg/kg) on edema degree of ACD was assessed and the expression levels of IFN-γ, TNF-α and IL-4 were detected by ELISA. Results: Desloratadine citrate disodium can reduce the edema degree of ears. The levels of IFN-γ, TNF-α and IL-4 in serum of ACD mice were higher than that in blank controls (P<0.01) and the levels of the three cytokines in serum were all decreased after interfered by desloratadine citrate disodium, with a dose-dependent. Conclusion: Desloratadine citrate disodium is effective in the treatment of allergic contact dermatitis, which may be through regulating the levels of IFN- γ, TNF- α and IL- 4

Key words: desloratadine citrate disodium')">

desloratadine citrate disodium, ACD, IFN-γ, TNF-α, IL-4