China Journal of Leprosy and Skin Diseases ›› 2018, Vol. 34 ›› Issue (1): 25-28.

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Up-regulation of IFI16 in fibroblasts irradiated by UVB

MA Huimin1 , LIU Wei2.   

  1. 1 Department of Dermatology, Electric Teaching Hospital of Capital Medical University，Beijing 100137, P.R. China; 2 Department of Dermatology, the General Hospital of the Air Force, Beijing 1000142, P.R. China
  • Online:2018-01-15 Published:2018-12-05

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Abstract: Objective: To detect the level of IFI16 in the fibroblasts irradiated by UVB. Methods: The fibroblasts were irradiated by triplicate UVB, and the levels of IFI16 mRNA and protein were detected by RT-PCR and western blot. Results: The levels of IFI16 mRNA and protein in the fibroblasts irradiated by UVB were 2.11±0.45 and 1.59±0.23 times more than those in normal fibroblasts (P<0.05). Conclusion: The level of IFI 16 was increased in the fibroblasts irradiated by UVB. IFI 16 may be involved in the process of fibroblasts photoageing.