Abstract: Mas-related G protein-coupled receptors, a novel type of G protein-coupled receptors, are specifically expressed in peripheral sensory neurons and mast cells. Mrgprs play an important physiologic role in itch or pain and may be a new target for anti-itching drugs. This review summarizes the current knowledge on the classification, expression, function in pruriceptive itch, intracellular signaling pathways and therapeutic potential of Mrgprs.

Key words: Mrgprs, pruriceptiveitch, histamine-independent, DRG neurons