Abstract: Objective: To analyze the correlation between hematological parameters and chronic urticaria. Methods: The level of serum total IgE, CRP, complement C3, complement C4, D2 mer, F1+2 fragment and FVIIa levels in 138 patients with chronic urticaria and 100 normal controls were detected. Multivariate logist regression analysis was used to detemine the correlation between the risk factors and the disease. Results：The levels of IgE, CRP, complement C3, complement C4, D2 mer, F1+2 fragment and FVIIa were higher in the patients than those in the controls, with significant differences (P<0.05). The antihistamines treatment was effective in 87 patients after treatment for 3 months. The levels of CRP, FVIIa, D2 and disease severity scores were higher in the non-effective patients than those in the sensitive patients to antihistamines, with significant differences (P<0.05). Multivariate logistic regression analysis showed that D2 mer was the main influencing factor for treatment (OR: 1.63, 95% CI 1.102-1.799, P < 0.05). The patients were divided into two groups according to the median D2 mer level (5.41 mg/L): group A with D2 mer level ≥5.41 mg/L and group B with the D2 mer level <5.41 mg/L. The recurrence rate in group A was 23.56% after two years follow-up, which was significantly higher than that in group B (12.14%), with a significant difference (P<0.001). Conclusion: A variety of inflammatory factors and coagulation factors may be involved in the pathogenesis of chronic urticaria and D2 mer may be associated with efficacy of treatment and recurrence.

Key words: chronicurticaria, inflammatory factors, coagulation factors