Abstract: Multidrug resistance of Neisseria gonorrhea is a challenge in the treatment of gonorrhea. It is found that efflux pump system is the main mechanism of multidrug resistance of gonococcus. Four efflux pump systems of Neisseria gonorrhea have been found: MtrCDE, MacAB, NorM and FarAB. MtrF pump protein has been found in some strains. The current research of the composition, function, gene regulation of efflux pump is reviewed in this paper.