Abstract: Objective: To assess the efficacy of prednisone combined with thalidomide in the treatment of severe type-2 leprosy reactions. Methods：Thirty patients with severe type-2 leprosy reaction were treated with prednisone, 30mg, once a day, and thalidomide, 100mg, three times a day. The drug was gradually reduced after symptoms were controlled, The total course was 4 months. Results: The recovery rate and effect rate were 86.84% and 94.73％. Conclusion: Prednisone combined with thalidomide is effective in the treatment of severe type-2 leprosy reaction.

Key words: severe II leprosy reaction, thalidomide, prednisone