Abstract: The data of 16 patients with Sweet's syndrome was analyzed retrospectively. Nine cases had Premonitory symptom was seen in 9 cases, drug history in 7, fever and rash in 11 including edematous erythema, papules and nodules, and bullous and pustules in 2. Biopsy showed papilla edema, neutrophil infiltration in the dermis. Nine cases were accompanied with other disease. 15 cases were treated with corticosteroid and 13 cases were cured. The clinical manifestations of Sweet ' s syndrome differ greatly and the patients are often accompanied with other diseases. Corticosteroid is effective.