Abstract: Objective: To assess the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating high risk human papilloma virus (HR-HPV) infection after loop electrosurgical excision procedure (LEEP). Methods：The patients with cervical intraepithelial neolasia Ⅱtreated by loop electrosurgical excision procedure, with normal Thinprep Cytologic Test (TCT) for 6 months and positivity for HR-HPV were selected from January 2015 to June 2016. The patients were divided into the treatment group and control group randomly. The patients in the treatment group were treated with 5-aminolevulinic acid photodynamic therapy (ALA-PDT), once a week, for 3 times. The patients in the control group were treated with interferon, 800 000 IU, once a day, 10 times each menstrual cycle for 3 months. Results: Forty-two patients were collected. The HR-HPV negative conversion?rates were?80% in?the treatment?group?(20 patients) and 36% in the control group, with a significant difference (P<0.05). Conclusion：ALA-PDT is effective in the treatment of HR-HPV after LEEP.

Key words: ALA-PDT, cervical intraepithelial neoplasias, loop electrosurgical excision procedure, high risk human papilloma virus