China Journal of Leprosy and Skin Diseases ›› 2018, Vol. 34 ›› Issue (7): 441-443，448.

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Follicular helper T cells and related dermatoses

YAN Tianmeng1,2, ZUO Yagang2   

  1. 1.Department of Dermatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053,China; 2. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100730，China
  • Online:2018-07-15 Published:2018-12-14
  • Contact: ZUO Yagang, E-mila: zuoyagang@263.com

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Abstract: Follicular helper T cells (Tfh cells) are distinguished from other CD4+T helper cells (Th cells). Tfh cells play an important role in the proliferation and differentiation of B cells and humoral immunity. Tfh cells were reported to play crucial roles in the autoimmune diseases，such as systemic lupus erythematosus, sjogren’s syndrome, allergic diseases and so on. Tfh cells and related disease is reviewed in this article.

Key words: Tfh cell, Bcl-6, CXCR5