Abstract: Objective: To report two cases of food-dependence exercise-induced anaphylaxis, and to summarize the characteristics and treatment methods of the disease after searching the literature. Methods: The data of two cases in our department and 95 cases of food-dependent exercise-induced anaphylaxis from CNKI and Wanfang database were retrospectively analyzed, including medical history, clinical manifestations and treatment. Results: Among the 97 patients, there were 51 males and 46 females with an average age of 37 years (7-71 years). All patients had a history of exercise before the onset of the disease, and 59.0% had severe exercise such as running. The clinical manifestations at the time of onset mainly involved skin and mucous membrane (100%). Wheat was the inducing food in 88 patients (90.7%). After treatment with epinephrine, antihistamines and glucocorticoids, the symptoms of all patients were relieved. Conclusion: Wheat is the most common allergic food, running is the most common induced exercise, and skin and mucosal manifestations are the most common. Adrenaline and glucocorticoids are the first-line treatments for acute episodes of food dependent exercise induced allergic reactions.

Key words: food-dependent exercise-induced anaphylaxis, wheat-dependent exercise-induced anaphylaxis