China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (6): 442-444.doi: 10.12144/zgmfskin202506442

• Case Reports • Previous Articles     Next Articles

Nodular fasciitis of the upper eyelid: a case report

LUO Wanting1,2, SHI Cuiping1,2, CHENG Shaohang1,2, YANG Fang1,2   

  1. 1 Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China; 2 Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen 518020, China
  • Online:2025-06-15 Published:2025-05-23

PDF (PC)

13

Like

Abstract: A 32-year-old female presented with a subcutaneous nodule on the left upper eyelid for one month. Histopathological examination showed fibroblastic proliferation in the dermis and subcutaneous tissue, with a large number of spindle cells arranged in bundles, small clefts visible between the cells, interstitial mucous-like changes, lymphocyte infiltration, and erythrocyte exudation. Immunohistochemical staining showed Vimentin and SMA（+）was positive, Ki-67 proliferation index was 10%, Desmin, CD34, EMA, CK, S100 were negitive. Genetic testing of the lesion (FISH method) detected a USP6 gene translocation. The diagnosis of nodular fasciitis was made. There was no recurrence after one year follow-up.

Key words: nodular fasciitis, USP6 gene