China Journal of Leprosy and Skin Diseases ›› 2026, Vol. 42 ›› Issue (1): 55-58.doi: 10.12144/zgmfskin202601055

• Case Reports • Previous Articles     Next Articles

Dupilumab in the treatment of papuloerythroderma of Ofuji: a case report

ZHOU Zhonglian, XIAO Yi, HUANG Yingxue, SU Juan, CHEN Mingliang, ZHANG Mi   

  1. Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
  • Online:2026-01-15 Published:2026-01-16

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Abstract: Papuloerythroderma of Ofuji (PEO) is a rare skin disorder characterized by diffuse erythroderma composed of papules coalescing into plaques with sparing of skin folds. Currently, the main therapeutic modalities for PEO include glucocorticoids, immunosuppressants, retinoids, and psoralen plus ultraviolet A (PUVA) therapy, among others, with suboptimal therapeutic efficacy. This paper reports a case of PEO successfully treated with dupilumab.

Key words: papuloerythroderma of Ofuji, dupliumab