China Journal of Leprosy and Skin Diseases ›› 2026, Vol. 42 ›› Issue (2): 139-144.doi: 10.12144/zgmfskin202602139

• Reviews • Previous Articles    

Post-translational modifications and psoriasis: from molecular mechanisms to therapeutic targets

HU Junjie1,2,3,4, WU Yifan1,2,3,4, TANG Huayang1,2,3,4   

  1. 1 Department of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; 2 Institute of Dermatology, Anhui Medical University, Hefei 230032, China; 3 Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei 230032, China; 4 Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University, Hefei 230032, China
  • Online:2026-02-15 Published:2026-01-28

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Abstract: Post-translational modification (PTM) serves as a core step in regulating the biological functions of proteins. Dysregulated expression of PTM-related enzymes and their substrates has been confirmed to be associated with the pathogenesis of psoriasis. This review summarizes common types of protein post-translational modifications and their roles in the pathogenesis of psoriasis, including that aberrant post-translational modifications can affect the functions of key substrates such as NF-κB, STAT3, keratin and IL-17A, thereby amplifying the Th17/Th1 immune response, inducing excessive proliferation of keratinocytes, promoting angiogenesis, and facilitating the formation of neutrophil extracellular traps (NETs).

Key words: psoriasis, post-translational modification, histone