Abstract: Objective: To analyze the characteristics of clinic, biopsy and biological detection in the patients with fish stab wound granulomas. Methods: The data of 20 patients with fish stab wound granulomas in our hospital were retrospectively analyzed. Results: 16 (80%) patients had a history of trauma and contact with aquatic products or water before the onset of the disease, and 4 (20%) patients had no obvious predisposing cause. All patients had skin lesions on the upper limb, and the lesions involved with one upper limb in 17 patients, involved both upper limbs in 3 patients. The mainly clinical feature was the primary rash, superficial breaching, or multiple nodules. Among the patients who underwent pathological examination, all of the results suggested an infectious granuloma. TB-IGRA was positive in 70% patients. 17 (85%) patients recovered within 6 months of treatment, 1 patient recovered by 10 months, and other 2 patients ware under follow-up. Conclusion: M.marinum infection of the skin is mostly associated with the patient's daily exposure to aquatic products in this study. Most lesions are mainly on the unilateral upper limb. The TB-IGRA positive  rate is high.

Key words: Mycobacterium marinum, infective granuloma, fish stab wound granuloma, swimming pool granuloma