Abstract: Objective: To access the efficacy of superficial X-ray therapy on 12 patients with palmoplantar warts in our hospital from September 2021 to June 2022. Methods: Refractory palmoplantar warts in all 12 patients were treated with multiple cryotherapy with poor efficacy. And the thickness of the lesions was from 3 to 5mm. The lesions in 12 patients were all given superficial X-ray therapy, with the tube voltage of 70 kV and the dose of 5Gy each time, once a week for 3 times. The patients were followed up for one month after the treatment. Results: 12 patients finished the treatment. The lesions subsided in 10 patients, and there is no recurrence after 1 month follow-up. of which one patient with adverse reaction of skin infection which healed after 4 weeks without leaving scars and pigmentation. New skin lesions occurred after treatment in one male patient, which was defined as recurrence. The skin lesions did not subside significantly in another male patient with multiple plantar warts and was lost to follow-up. Conclusion: In our study, superficial X-ray shows good efficacy for refractory palmoplantar warts, with few adverse reactions, low recurrence rate, short course of treatment.

Key words: superficial X-ray, refractory warts, palmoplantar warts