Abstract: The data of 106 cases of skin adverse reactions after vaccination of COVID-19 vaccine in our hospital from October 2021 to October 2022 were analyzed. The incidence of skin adverse reactions after the first, second and third doses of COVID-19 vaccine were 58.49%, 25.47% and 16.04% respectively. In addition, the adverse reactions of patients with skin diseases after vaccination accounted for 19.81% of all skin adverse reactions. Urticaria-like rash was the most common skin adverse reaction after vaccination, followed by eczematoid rash and herpes zoster with an incidence of 42.45%, 30.19% and 11.32%. Other rare skin adverse reactions after COVID-19 vaccination included pityriasis rosea, erythema multiforme, chickenpox, psoriasis, erythroderma, measles like rash and vitiligo. Among the patients with three doses of COVID-19 vaccine, 18 patients had two skin adverse reactions, and 3 patients had three skin adverse reactions. For these skin adverse reactions, most of the treatment measures were symptomatic treatment, such as oral antihistamine loratadine tablets, and external use of weak to medium effect corticosteroid ointment, the patients could be cured in about 2-3 weeks.

Key words: COVID-19 vaccine;skin adverse reaction, immune reaction