掌跖脓疱病,IL36RN,基因突变 ," /> 掌跖脓疱病,IL36RN,基因突变 ,"/> Associationof IL36RN mutation with palmoplantar pustulosis

China Journal of Leprosy and Skin Diseases ›› 2019, Vol. 35 ›› Issue (1): 6-8.doi: 10.12144/zgmfskin201901006

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Associationof IL36RN mutation with palmoplantar pustulosis

FU Fanghui1,2, FU Xi'an1,2, WANG Zhenzhen2, YU Gongqi2, LIU Hong1,2, ZHANG Furen1,2   

  1. 1.Department of Dermatology, Shandong Provincial Hospital for Skin Disease, Shandong University, Jinan 250022, China; 
    2.Shandong Provincial Institute of Dermatology and Venereology,  Jinan 250022, China
  • Online:2019-01-15 Published:2019-02-26
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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Abstract: Objective: To determine the association of IL36RN gene mutation with palmoplantar pustulosis (PPP). Methods: DNA was extracted from peripheral blood of 96 patients with PPP and 144 healthy controls. All exons and flanking sequences of IL36RN gene were amplified by polymerase chain reaction and the productions were sequenced. Results: The mutation of c.115+6T>C (p.Arg10ArgX1) was identified in three patients and two healthy controls. The mutation of c.140A>G (p.Asn47Ser) was identified in three patients and four controls. There was no significant difference in the mutation rate of c.115+6T>C and c.140A>G in IL36RN between PPP patients and healthy controls (P=0.67，OR=0.65, 95% CI: 0.20~2.09). Conclusion: The mutations in IL36RN gene are not associated with PPP.

Key words: palmoplantar pustulosis, IL36RN, gene mutation