Abstract: Lymphocytic variant of hypereosinophilic syndrome is a rare subtype of hypereosinophilic syndrome. A 69-year-old male patient had repeated erythema papulae on trunk and limbs with pruritus for 2 years, and was admitted to hospital one month after aggravation. Peripheral blood eosinophils increased significantly. Skin histopathology showed eosinophil infiltration in the superficial dermis. Bone marrow cytology examination revealed active proliferation of nucleated cells in the bone marrow, with eosinophils accounting for 5.5%. Flow cytometry of the bone marrow detected 27.61% abnormal T lymphocytes (CD4 positive and CD8 negative). Gene detection sites of BCR/ABL, PDGFRα, PDGFRβ, FGFR1, and PCM1/JAK2 genes were all negative. After receiving glucocorticoid, antihistamine and supporting symptomatic treatment, the patient improved and was discharged.

Key words: hypereosinophilic syndrome, lymphocytic variant