Abstract: Lymphocytic variant of hypereosinophilic syndrome (L-HES) is a kind of hypereosinophilia caused by abnormal clonal T lymphocytes. It is characterized by the presence of phenotypically abnormal T lymphocyte populations in bone marrow or peripheral blood. Herein， we report a 49-year-old man with a 13-year history of hypereosinophilia. The multiple lymph nodes were enlarged since half a year ago, and the histopathological examination showed dermatopathic lymphadenitis of lymph nodes with reactive hyperplasia and eosinophilic infiltration. Bone marrow flow cytometry detected a group of abnormal T lymphocytes with CD3（-）CD4（+）CD8（-）CD5brightCD7（-）. Oral methylprednisolone was effective（36 mg/d）. Methylprednisolone dose was reduced to 8 mg/d after discharge and the disease is well controlled.

Key words: rash, lymphadenopathy, hypereosinophilic syndrome, lymphocytic variant of hypereosinophilic syndrome