Abstract: Reactive angioendotheliomatosis is a rare benign reactive vascular proliferative disorder. We report the case of a 63-year-old man who presented with violaceous red patches on the chest and abdomen, accompanied by pruritus for one year, which became generalized over one month. Histopathological examination of the skin lesions revealed hyperkeratosis, proliferation of capillaries and endothelial cells in the superficial and middle dermis, and fibrin thrombi in most vascular lumens. A diagnosis of reactive angioendotheliomatosis was made. Following admission, the patient was administered methylprednisolone (16 mg daily) and cyclophosphamide (50 mg daily). After three days, the skin lesions showed improvement, and the patient was discharged. Post-discharge, he was prescribed oral prednisone acetate (20 mg daily), which was gradually tapered to 2.5 mg daily over a total treatment period of two years. At the most recent follow-up (one year after discontinuation of medication), the rash had largely resolved with no new lesions.

Key words: reactive angioendotheliomatosis, vascular diseases