Abstract: A 68-year-old male presented with recurrent pruritic papules, vesicles, and nodules on the limbs for over 50 years. Histopathological examination revealed hyperkeratosis, subepidermal blister formation, and mild perivascular inflammatory infiltrate in the dermis. Immunofluorescence showed negative expression of IgG, C3, IgM, and IgA. The patient was diagnosed with pruriginous dystrophic epidermolysis bullosa pruriginosa (DEBP). Conventional therapies, including antihistamines, immunosuppressants, and corticosteroids, provided no significant improvement, with persistent pruritus. Dupilumab, a fully humanized monoclonal antibody, has demonstrated efficacy in atopic dermatitis, bullous pemphigoid, and prurigo nodularis, but clinical data on its use for DEBP remain limited. In this case, dupilumab treatment resulted in partial flattening of lesions, and marked alleviation of pruritus.

Key words: dystrophic epidermolysis bullosa, pruriginosa, dupilumab