Abstract: Primary cutaneous amyloidosis (PCA) is a refractory disease with high recurrence rate and no standardized treatment. This article reports a case of successful treatment of PCA with dupilumab. The patient presented with papules with itching on the neck and back, and limbs for 2 years, which was confirmed by pathology. Conventional treatments were ineffective, and dupilumab therapy was administered. On the day of treatment, the patient's itching was alleviated, and after 12 weeks, the skin rashes subsided. Two months after drug withdrawal, no new skin rashes or adverse reactions were observed.

Key words: dupilumab, primary cutaneous amyloidosis, lichen amyloidosis