Abstract: We summarized 4 patients with severe bullous pemphigoid successfully treated by dupilumab combined with glucocorticoid, providing reference for the treatment of severe bullous pemphigoid. Of 4 patients, 3 had obvious itching accompanied by eosinophilia and the disease was controlled on day 2, 3, and 1st after treatment with glucocorticoid combined with dupriuzumab, respectively, the eosinophil count decreased to normal on day 6, 9, and 3rd, the dose of glucocorticoid began to be reduced on day 4, 10, and 4th. The other patient with concomitant tumors, had no obvious itching and normal eosinophil count, the condition was controlled after 10 days of medication, and the dose of glucocorticoid was reduced 14 days later.  Dupilumab combined with glucocorticoid is an effective method for the treatment of severe bullous pemphigoid patients.

Key words: dupilumab, bullous pemphigoid, glucocorticoid