Abstract: Nodular cutaneous amyloidosis is a rare subtype of cutaneous amyloidosis, and two cases are reported herein. Patient 1 was a 44-year-old male who presented with a red firm papule on the left side of the nose for more than 1 year. Patient 2 was a 54-year-old female who had papules on the nose for more than 10 years; scattered firm semicircular yellow to skin-colored papules were visible on the nose and the right corner of the mouth, some of which merged into plaques, and she was once misdiagnosed as rosacea. Both patients were diagnosed with nodular cutaneous amyloidosis by skin pathological examination and special staining, and were given intralesional injection of compound betamethasone, resulting in shrinkage of the nodules.

Key words: nodular cutaneous amyloidosis