China Journal of Leprosy and Skin Diseases ›› 2026, Vol. 42 ›› Issue (7): 515-519.doi: 10.12144/zgmfskin202607515

• Clinical Researches • Previous Articles     Next Articles

Cutaneous lymphadenoma: two cases report and literature review

HAN Xiangchun1, ZHANG Chunmei2, JI Haifeng3, CANG Yan3, SUN Na1, SHANG Ran1, ZHENG Liqiang3   

  1. 1 Department of Pathology, Beichen Traditional Chinese Medicine Hospital, Tianjin 300400, China; 2 Department of Dermatology, Beichen Traditional Chinese Medicine Hospital, Tianjin 300400, China; 3 Department of Dermatology, 81 Group Military Hospital of Chinese PLA Army, Zhangjiakou 075000, China
  • Online:2026-07-15 Published:2026-06-29

Abstract: We reported two cases of cutaneous lymphadenoma (CL) and reviews the relevant literature. A total of 96 well-documented cases of CL were retrieved, among which 98% were acquired with no gender predilection. The average age and duration was 44.53±17.50 years, 6.47±7.79 years, respectively. CL lesions mainly involve the face and present with single papule or nodule, usually diameter <1 cm. Epithelial cell islands, lymphocyte infiltration, and connective tissue proliferative matrix are the main histopathological features of CL. Immunohistochemistry is helpful for differential diagnosis and identification of histological origin. Surgical resection is often used for treatment.

Key words: lymphadenoma, cutaneous, clinical feature, histopathology, immune phenotype