中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (2): 86-88.doi: 10.12144/zgmfskin201902086

• 论著 • 上一篇    下一篇

儿童特应性皮炎严重程度与血清25-羟维生素D和总IgE水平的相关性

张媛  王慧丛  颜敏   

  1. 胜利油田中心医院,山东东营，257000
  • 出版日期:2019-02-20 发布日期:2019-03-08
  • 通讯作者: 颜敏，E-mail: 18661399259@163.com

Relationship between clinical severity of atopic dermatitis in children and the levels of vitamin D and total IgE

ZHANG Yuan, WANG Huicong, YAN Min   

  1. Shengli Oilfield Central Hospital, Dongying 257000, China
  • Online:2019-02-20 Published:2019-03-08
  • Contact: YAN Min, E-mail: 18661399259@163.com

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摘要： 目的：明确儿童特应性皮炎患者特应性皮炎严重程度与血清25-羟维生素D和IgE水平的相关性。方法：参考SCORAD评分法评估60例特应性皮炎患者疾病严重程度，并检测特应性皮炎患者及55例对照组血清25-羟基维生素D3水平以及特应性皮炎患者总IgE水平。结果：特应性皮炎组患者血清25-羟维生素D水平(16.13±6.68)ng/mL低于对照组(19.81±8.24)ng/mL，差异有统计学意义（P<0.05）。根据SCORAD评分，特应性皮炎患者中33例为轻度、20例为中度，7例为重度。轻度组血清25-羟基维生素D3水平为(18.69±7.01)ng/mL，高于中度(12.81±4.35)ng/mL，差异有统计学意义（P<0.05）。血清25-羟维生素D与SCORAD评分之间有显著负相关（P<0.05）。IgE水平与SCORAD评分之间无相关性（P>0.05）。结论：AD患者血清25-羟基维生素D与AD严重程度呈负相关。

关键词: 特应性皮炎, 疾病严重程度指数, 25-羟维生素D, IgE

Abstract: Objective: To determine the correlation between the levels of serum vitamin D and IgE with the clinical severity of atopic dermatitis (AD) in children. Methods: The clinical severity of AD was evaluated with the SCORAD score. The levels of serum 25- hydroxide vitamin D3 and total IgE were detected in AD patients and 55 control subjects. Results: The level of vitamin D in AD group was 16.13±6.68ng/mL, which was lower than that in the control group (19.81±8.24 ng/mL), with a significant difference（P<0.05）. According to the SCORAD score, the patients with AD were divided into three groups: mild group (33 cases), moderate group (20 cases) and severe group (7 cases). The level of vitamin D in mild group was 18.69±7.01ng/mL, which was higher than that in the moderate group (12.81±4.35ng/mL), with a significant difference (P<0.05). There was a significant negative correlation between the level of vitamin D and the SCORAD score (P<0.05). There was no significant correlation between vitamin D and SCORAD score (P>0.05). Conclusion: Serum 25-hydroxyvitamin D3 level is negatively correlated with the severity of AD.

Key words: atopic dermatitis, disease severity index, vitamin D, IgE