中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (2): 115-119.doi: 10.12144/zgmfskin201902115

• 综述 • 上一篇    下一篇

ESRPs在上皮间质转化中的作用及其调控机制研究进展

王白鹤  孙建方   

  1. 中国医学科学院皮肤病研究所，南京，210042
  • 出版日期:2019-02-20 发布日期:2019-03-08
  • 通讯作者: 孙建方，E-mail：fangmin5758@aliyun.com

Update of roles and regulation of ESRPs in Epithelial-Mesenchymal Transition

WANG Baihe, SUN Jianfang   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2019-02-20 Published:2019-03-08
  • Contact: SUN Jianfang, E-mail: fangmin5758@aliyun.com

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摘要： 上皮-间质转化(EMT)是将极化上皮细胞转化为具有间充质细胞的过程，它由EMT相关转录因子调节，同时还在转录后水平受可变剪接调控。本文对上皮剪接调节蛋白（ESRPs）在EMT进程中的作用及其调控机制研究进行综述。

关键词: 上皮间质转化, 上皮剪接调节蛋白, 可变剪接

Abstract: The transformation of polarized epithelial cells into cells with mesenchymal characteristics by the morphogenetic process of epithelial–mesenchymal transition (EMT) is a characterized process. It is a program driven by changes in gene expression induced by several EMT-specific transcription factors. EMT may also be regulated post-transcriptionally by alternative splicing(AS). Update on the roles and regulation of epithelial splicing regulatory proteins (ESRPs) in EMT process is presented in the article.

Key words: Epithelial-Mesenchymal transition, epithelial splicing regulatory proteins, alternative splicing