中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (2): 80-82.doi: 10.12144/zgmfskin201902080

• 论著 • 上一篇    下一篇

M1/M2型巨噬细胞在尖锐湿疣皮损中的表达

刘睿1  孙弦1  胡珍1  吴庭1  曹育春2  彭才智1   

  1. 1武汉市第三医院皮肤科，武汉，430070
    2华中科技大学同济医学院附属同济医院皮肤科，武汉，430000
  • 出版日期:2019-02-20 发布日期:2019-03-07
  • 通讯作者: 刘睿，E-mail: 331026747@qq.com

The expression of M1/M2 macrophages in condyloma acuminatum

LIU Rui1, SUN Xian1,HU Zhen1, WU Ting1, CAO Yuchun2, PENG Caizhi1   

  1. 1. Department of Dermatology,Wuhan Third Hospital,Wuhan 430070, China; 
    2. Department of Dermatology,Tongji Hospital,Tongji Medical College,Huazhong University of science and Technology,Wuhan 430000, China
  • Online:2019-02-20 Published:2019-03-07
  • Contact: LIU Rui, E-mail：331026747@qq.com

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摘要： 目的：检测尖锐湿疣皮损中M1/M2型巨噬细胞的表达。方法：采用免疫组织化学SP法检测30例尖锐湿疣皮损组织及15例正常组织中诱导型一氧化氮合酶（iNOS）标记的M1型巨噬细胞和CD163标记的M2型巨噬细胞的表达。结果：尖锐湿疣皮损组织中iNOS+M1型巨噬细胞的浸润数量为（6.16±3.32）/HP与正常组织（6.76±0.87）/HP比较，无统计学差异（P＞0.05）。CD163+M2巨噬细胞的浸润数量（22.30±6.27）/HP高于正常组织（9.81±4.23）/HP，差异有统计学意义（P＜0.05）。iNOS+M1型和CD163+M2型巨噬细胞在CA组织中的浸润呈负相关（P＜0.05）。结论：尖锐湿疣皮损中浸润的巨噬细胞以M2型为主，可能在尖锐湿疣逃避机体免疫反应中发挥重要作用。

关键词: 尖锐湿疣, M1型巨噬细胞, M2型巨噬细胞, iNOS, CD163

Abstract: Objective: To detect the expression of M1/M2 macrophages in the lessions of condyloma acuminatum(CA). Methods: The expression  of iNOS-labeled M1 macrophages and CD163-labeled M2 macrophages were detected by immunohistochemistry streptavidin-peroxidase methodin in CA lesions of 30 patients and15 normal controls. Results: The number of iNOS+ M1 macrophage in CA lesions and normal tissues was (6.16±3.32)/HP and (6.76±0.87)/HP, with no significant difference (P>0.05). The number of CD163+M2 macrophages in CA lesions and normal tissue was (22.30±6.27)/HP and (9.81±4.23)/HP，with a significant difference (P<0.05). There was a negative correlation between the level of iNOS+ M1 and CD163+ M2 macrophages in CA lesions (P<0.05). Conclusion: Macrophages infiltration in CA lesions mainly are M2, which may play an important role in CA escaping immune responses.

Key words: condyloma acuminata, M1 macrophages, M2 macrophages, iNOS, CD163