中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (7): 438-440.doi: 10.12144/zgmfskin202107438

• 论著 • 上一篇    下一篇

射频消融术治疗宫颈尖锐湿疣ALA-PDT治疗后残留感染灶的疗效

陈真云1,薛莉2*,陈洪晓3*,王秀芹4,李晓红1,牛洪朋1,丁丹丹1    

  1. 1临沂市肿瘤医院妇一科，山东临沂，276000；
    2威海市威海卫人民医院妇产科，山东威海，264200；
    3临沂市人民医院皮肤科，山东临沂，276000；
    4临沂市第三人民医院皮肤科，山东临沂，276000
    *共同第一作者
  • 出版日期:2021-07-15 发布日期:2021-06-25
  • 通讯作者: 陈洪晓，E-mail: 393053747@qq.com

Efficacy of radiofrequency ablation on residual lesions of cervical condyloma acuminatum after ALA-PDT treatment

CHEN Zhenyun1, XUE Li2*, CHEN Hongxiao3*, WANG Xiuqin4, LI Xiaohong1, NIU Hongpeng1, DING Dandan1   

  1. 1 Department of Gynecologic Oncology, Linyi Tumor Hospital, Linyi 276000, China; 
    2 Department of Obstertrics and Gynecology, Weihaiwei Peoples Hospital of Weihai, Weihai 264200, China; 
    3 Department of Dermatology, Shandong Linyi Peoples Hospital, Linyi 276000, China; 
    4 Department of Dermatology, Linyi Third Peoples Hospital, Linyi 276000, China
    * Co-first author
  • Online:2021-07-15 Published:2021-06-25
  • Contact: CHEN Hongxiao, E-mail: 393053747@qq.com

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摘要： 目的：评价射频消融术治疗5-氨基酮戊酸光动力(ALA-PDT)治疗后宫颈残存尖锐湿疣的疗效。方法：将ALA-PDT治疗3次后宫颈残存尖锐湿疣的患者随机分为2组，研究组采用射频消融术治疗，对照组继续ALA-PDT治疗1次。观察治愈率、HPV感染转阴率及3个月后的复发率和患者满意度情况。结果：共治疗62例患者，其中研究组32例和对照组30例，治愈率分别为96.88%和76.67%，差异有统计学意义（χ2=5.627，P=0.024）。研究组和对照组3个月HPV转阴率为84.38%和60.00%，差异有统计学意义（χ2=4.623，P=0.046）。研究组和对照组患者治疗总满意度分别为92.75%和66.67%，差异有统计学意义（χ2=13.857，P=0.001）。结论：射频消融术在治疗ALA-PDT治疗后宫颈残存尖锐湿疣的治愈率及HPV转阴率高。

关键词: 尖锐湿疣, 宫颈, 射频消融术, 干扰素, 5-氨基酮戊酸光动力, 人乳头瘤病毒

Abstract: Objective: To access the efficacy of radiofrequency ablation on the lesions of cervical condyloma acuminatum after ALA-PDT treatment. Methods: The patients with cervical condyloma acuminatum after 3 times of ALA-PDT treatment were randomly divided into 2 groups. The study group was treated with radiofrequency ablation, while the control group was treated with ALA-PDT for 1 time. The cure rate, HPV negative conversion rate, the recurrence after 3 months and the satisfaction of the patients were assessed. Results: A total of 62 patients were included in the study, including 32 cases in the study group and 30 cases in the control group. The cure rates were 96.88% and 76.67% respectively, with a significant difference (χ2=5.627, P=0.024). The HPV negative conversion rates at 3 months were 84.38% and 60.00% respectively and the difference was significant (χ2=4.623, P=0.046). The patients satisfaction in the study group was 92.75%, which was higher than that in the control group (66.67%), with a significant difference (χ2=13.857, P=0.001). Conclusion: Radiofrequency ablation on the lesions of cervical condyloma acuminatum after ALA-PDT treatment has a high cure rate and high HPV negative conversion rate. 

Key words: condyloma acuminatum, cervix, radiofrequency ablation, interferon, ALA-PDT, human papilloma virus