中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (7): 412-418.doi: 10.12144/zgmfskin201907412

• 论著 • 上一篇    下一篇

近25年结节性红斑患者中结核感染特点的Meta分析

钟娇娇1  贺雨南2  张军民1   

  1. 1中山大学孙逸仙纪念医院皮肤科，广州，510120
    2中山大学孙逸仙纪念医院妇产科，广州，510120
  • 出版日期:2019-07-15 发布日期:2019-07-11
  • 通讯作者: 张军民，E-mail：junminmx@163.com

Prevalence of tuberculosis in the patients with erythema nodosum: meta-analysis

ZHONG Jiaojiao1, HE Yunan2, ZHANG Junmin1   

  1. 1. Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; 
    2. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  • Online:2019-07-15 Published:2019-07-11
  • Contact: ZHANG Junmin, E-mail: junminmx@163.com

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摘要： 目的：明确1993-2018年结节性红斑(EN)患者中结核(TB)感染特点。方法：2位研究者独立检索1993年1月至2018年9月PubMed、Embase、MEDLINE、CNKI、CBM、万方数据库筛选出符合纳入标准的文献，采用STATA 12.0软件通过Meta分析方法进行单个率的合并分析。结果：共纳入27篇文献，包括国内11篇（1019例患者，其中结核性结节性红斑患者277例，感染率25.4%），国外16篇（995例，其中结核性结节性红斑患者52例，感染率6%）。国内亚组分析显示东部、中部及西部地区EN患者中结核感染率分别为16.0%、27.9%和32.5%，Meta回归显示地区因素而非年份因素可解释异质性来源(P=0.02)。结节性红斑患者结核病灶为肺结核、淋巴结核、其他类型结核（如：结核性胸膜炎、卵巢结核等）、仅PPD强阳性，分别占44.4%、11.1%、7.1%及38.2%。结论：大多数EN患者没有明显的结核症状，因此应尽量寻找潜在的结核病感染病灶。

关键词: 结核, 结节性红斑

Abstract: Objective: To investigate the epidemiological aspect of tuberculosis (TB) infection  among the patients with erythema nodosum (EN) from 1993 to 2018 in China. Methods: The relevant studies were searched from PubMed, Embase, MEDLINE, CNKI, CBM and Wanfang databases from January 1993 to September 2018 and analyzed with Meta-analysis through STATA 12.0. Results: A total of 27 articles were included in the final analysis, including 11 domestic literatures (1019 EN patients) and 16 foreign literatures (995 patients). Out of 1019 Chinese patients, 277 EN patients had TB infection (25.4%) and out of 995 foreign patients, 52 patients had TB infection (6%).  Subgroup analysis showed that the prevalence of TB in the patients with EN in the eastern, central and western regions of China were 16.0%, 27.9%, and 32.5%, respectively. Meta-regression showed regional factors (P=0.02) rather than year factors explained the source of heterogeneity. In the studies in which more detail information was presented, the distribution of tuberculous foci, the proportion of tuberculosis, pulmonary tuberculosis, lymphatic tuberculosis, other types such as tuberculous pleurisy, ovarian tuberculosis, and only with strong positive PPD were 44.4%, 11.1%, 7.1%, and 38.2%, respectively. Conclusion: Since most EN patients do not have significant clinical symptoms (signs), more efforts should be made to search for the potential infections of tuberculosis.

Key words: tuberculosis, erythema nodosum