中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (4): 287-290.doi: 10.12144/zgmfskin202304287

• 病例报告 • 上一篇    下一篇

以发热及皮疹为首发表现的新生儿狼疮一例并文献复习

杨玲1,张宇强1,胡平1,贾玲玲1,李涛1,水华2   

  1. 1湖北医药学院附属太和医院，湖北十堰，442000；
    2武汉大学中南医院肾病内科，湖北武汉，430060
  • 出版日期:2023-04-15 发布日期:2023-03-28

Neonatal lupus erythematosus with fever and rash as the first manifestation: a case report

YANG Ling1, ZHANG Yuqiang1, HU Ping1, JIA Lingling1, LI Tao1, SHUI Hua2   

  1. 1 Taihe Hospital Affiliated to Hubei Medical College, Shiyan 442000, China; 2 Department of Nephrology, Central South Hospital, Wuhan University, Wuhan 430060, China
  • Online:2023-04-15 Published:2023-03-28

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摘要： 患儿，男，21天。全身皮疹伴持续发热2天，且出现进行性精神反应差、腹胀、呼吸急促等表现，患儿出生前后有肺结核密切接触史。抗核抗体(滴度)1∶1000、抗干燥综合征抗原A(SSA)抗体：阳性、干燥综合征抗原B（SSB）抗体：阳性。抗Ro52抗体：阳性，综上诊断为新生儿红斑狼疮，经积极使用人免疫球蛋白1 g/kg，患儿体温于48 h内缓慢下降，皮疹逐渐减轻，病情好转。

关键词: 新生儿狼疮, 皮疹, 发热, 结核

Abstract: A 21-day-old newborn infant presented with persistent fever and rashes all over the body for 2 days with progressive poor spirit, bloating, shortness of breath, even close contact with tuberculosis around birth, with antinuclear antibody (titer) 1∶1000, positive for anti Sjogren's syndrome antigen A (SSA) antibody, Sjogren's syndrome antigen B (SSB) antibody, and anti-Ro52 antibody. The diagnosis of neonatal lupus erythematosus was made. After treatment of gamma globulin (IVIG), 1g/kg, the child's temperature was dropping gradually within 48 hours, rashes reduced gradually.

Key words: neonatal lupus erythematosus, rash, fever, tuberculosis