中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (9): 564-567.doi: 10.12144/zgmfskin201909564

• 综述 • 上一篇    下一篇

鲜红斑痣发病及治疗相关机制研究进展

王美玲1,2  刘华绪2   

  1. 1济南大学山东省医学科学院医学与生命科学学院,山东济南,250000

    2山东省皮肤病医院&山东省皮肤病性病防治研究所，山东第一医科大学&山东省医学科学院, 山东济南，250022

  • 出版日期:2019-09-15 发布日期:2019-09-16
  • 通讯作者: 刘华绪，E-mail: liueternal@163.com

Update of the pathogenesis and therapeutic mechanism of port wine stain

WANG Meiling1,2, LIU Huaxu2   

  1. 1.School of Medicine and Life Science, Jinan University-Shandong Academy of Medical Sciences, Jinan 250000, China; 2. Shandong Provincial Hospital for Skin Disease & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2019-09-15 Published:2019-09-16
  • Contact: LIU Huaxu, E-mail: liueternal@163.com

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摘要： 鲜红斑痣(PWS)是临床常见的毛细血管及毛细血管后静脉的畸形，PWS绝大部分为先天性，患病率为3/1000~5/1000。脉冲染料激光是该病的治疗首选，但治疗率尚不理想，其原因在于部分血管不能被充分封闭，部分血管治疗后再通和再灌注。本文对鲜红斑痣的发病机制、治疗机制及治疗后血管再生机制进行了综述。

关键词: 鲜红斑痣, 基础研究, 血管生成抑制剂

Abstract: Port wine stain (PWS) is a type of common abnormality of capillaries and postcapillary venule. Most of PWS is congenital, with a prevalence of 3/1000-5/1000. Pulsed dye laser is the first choice for the treatment of PWS, but the efficacy is not ideal due to the fact that some blood vessels cannot be fully closed, and some blood vessels will get recanalization and reperfusion after treatment. The pathogenesis, therapeutic mechanism and the mechanism of angiogenesis after treatment of PWS were reviewed in the paper.

Key words: port wine stain, mechanism, angiogenesis inhibitors