中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (2): 117-121.doi: 10.12144/zgmfskin202002117

• 综述 • 上一篇    下一篇

幼年性黄色肉芽肿基因突变研究进展

张文青1,2,余霞1，2,李明1，2,姚志荣1，2   

  1. 1上海交通大学医学院附属新华医院皮肤科，上海，200092；2上海交通大学医学院皮肤病研究所，上海，200092
  • 出版日期:2020-02-15 发布日期:2020-03-18
  • 通讯作者: 姚志荣，E-mail：yaozhirong@xinhuamed.com.cn

Update of gene mutations associated with Juvenile Xanthogranuloma

ZHANG Wenqing1,2, YU Xia1,2, LI Ming1,2, YAO Zhirong1,2   

  1. 1 Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; 2 Institute of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2020-02-15 Published:2020-03-18
  • Contact: YAO Zhirong, E-mail: yaozhirong@xinhuamed.com.cn

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摘要： 幼年性黄色肉芽肿（JXG）是一类主要发生在婴儿和儿童的非朗格汉斯组织细胞增生性疾病，部分幼年性黄色肉芽肿患者存在基因突变，该文针对幼年性黄色肉芽肿基因突变最新研究进展作一综述。

关键词: 幼年性黄色肉芽肿, 基因突变, BRAFV600E基因, NF1基因

Abstract: Juvenile xanthogranuloma is a kind of non-Langerhans cell proliferative disease and mostly occurred in the infants and children. Some patients with juvenile xanthogranuloma have genetic mutations. The update of the gene-mutated juvenile xanthogranuloma is reviewed in this paper.

Key words: juvenile xanthogranuloma, gene mutation, BRAFV600E gene, NF1 gene