中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (3): 147-150.doi: 10.12144/zgmfskin202003147

• 论著 • 上一篇    下一篇

带状疱疹后遗神经痛相关危险因素分析

孟丹1,林维茹1,刘国艳2   

  1. 1潍坊医学院，山东潍坊，261041；2潍坊医学院附属医院皮肤科，山东潍坊，261041
  • 出版日期:2020-03-15 发布日期:2020-03-30
  • 通讯作者: 刘国艳，E-mail: wfliuguoyan@126.com

Analysis of the risk factors for postherpetic neuralgia

MENG Dan1, LIN Weiru1, LIU Guoyan2   

  1. 1 Department of Dermatology, Weifang Medical University, Weifang 261041, China；2 the Affiliated Hospital of Weifang Medical University, Weifang 261041, China
  • Online:2020-03-15 Published:2020-03-30
  • Contact: LIU Guoyan, E-mail: wfliuguoyan@126.com

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摘要： 目的：明确带状疱疹后遗神经痛(postherpetic neuralgia，PHN)的危险因素。方法：分析潍坊医学院附属医院2017年9月至2019年2月带状疱疹住院患者的临床资料，依据发病后1个月是否有PHN，分为病例组和对照组。对两组患者进行单因素及多元logistic回归分析。结果：共筛选出513例患者，其中111例发生PHN（21.6%）。单因素分析示年龄、吸烟史、部位、皮疹面积、临床分型、前驱症状、早期治疗时间、使用糖皮质激素、糖尿病与PHN的发生有关。多因素Logistic回归分析结果显示，PHN的危险因素有年龄≥60岁、有吸烟史、发病诱因为精神/焦虑、初始治疗时间＞7天、急性期重度疼痛和糖尿病史(OR=6.013、3.391、6.800、22.071、21.996、3.163， 95％CI：1.694～21.341、1.219～9.436、1.310～35.296、4.049～120.314、2.864～168.946、1.281～7.811，均P＜0.05)。结论：年龄＞60岁、有吸烟史、发病诱因为精神/焦虑、早期治疗时间＞7天、重度急性期疼痛、糖尿病是PHN发生的危险因素。

关键词: 带状疱疹, 带状疱疹后遗神经痛, 危险因素

Abstract: Objective: To determine the risk factors of postherpetic neuralgia (PHN). Methods: The data of the patients with herpes zoster (HZ) was collected from the database of our hospital from September 2017 to February 2019. The patients were divided into observation group and control group (with or without PHN after 1 month of the onset of HZ). The data of the patients was analyzed with univariate and multivariate logistic regression analysis. Results: The data of 513 HZ patients was analyzed, of whom 111 patients suffered from PHN (21.6%). Single factor in univariate analysis showed age, smoking, site of the lesion, range involved clinical classification, prodrome, early treatment after onset, glucocorticoid use and diabetes mellitus were associated with PHN. Multivariate logistic regression analysis indicated that age ≥60 years old, smoking, anxiety state, early use of antiviral therapy after onset of the disease (within 7 days), pain during the acute stage of herpes zoster and diabetes were statistically significant associated with PHN (OR=6.013, 3.391, 6.800, 22.071, 21.996, 3.163, 95% CI: 1.694-21.341, 1.219-9.436, 1.310-35.296, 4.049-120.314, 2.864-168.946, 1.281-7.811; P＜0.05) . Conclusion: Age ≥60, smoking history, anxiety status, early using antiviral therapy after onset of the disease pain during the acute stage, diabetes are the risk factors associated with PHN. 

Key words: herpes zoster, postherpetic neuralgia, risk factors