中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (8): 479-482.doi: 10.12144/zgmfskin202008479

• 短篇论著 • 上一篇    下一篇

获得性大疱性表皮松解症误诊一例并文献复习

王娜,刘红,颜潇潇,潘付堂,施仲香,张福仁   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2020-08-15 发布日期:2020-08-11
  • 通讯作者: 张福仁，E-mail: zhangfuren@hotmail.com

Misdiagnosis of acquired bullous epidermolysis: a case report and literature review

WANG Na, LIU Hong, YAN Xiaoxiao, PAN Futang, SHI Zhongxiang, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2020-08-15 Published:2020-08-11
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 报道一例反复误诊的获得性大疱表皮松解症并对相关文献进行复习。患者，女，25岁。皮疹泛发全身，主要表现为张力性水疱，疱壁紧张，尼氏征阴性，在外院误诊为天疱疮、线状IgA大疱病。组织病理检查示:表皮下水疱；盐裂IIF：IgG沉积在真皮侧; DIF:表皮基底膜IgG、C3、IgM、IgA带状沉积，ELISA：BP180，BP230均阴性，诊断为获得性大疱性表皮松解症，给予甲泼尼龙、氨苯砜、人免疫球蛋白、吗替麦考酚酯等治疗，病情好转。

关键词: 大疱表皮松解症, 获得性, 反复误诊

Abstract: A 25-year-old female with acquired bullous epidermolysis (EBA) was reported and related literature was reviewed. The patient presented with tense blisters, negative Nikolsky's sign and once was  misdiagnosed as pemphigus, linear IgA bullous dermatosis in other hospitals. Biopsy showed blaster in subepidermal. Salt-split skin indirect immunofluorescence showed IgG deposition in dermis and indirect immunofluorescence showed basement film belt deposition of IgG, C3, IgM and IgA. Elisa showed negative BP180 and BP230. The diagnosis of EBA was made. The patient was treated with methylprednisolone, dapsone, human immunoglobulin, mycophenol ester and the condition improved.

Key words: bullous epidermolysis, acquired, repeated misdiagnosis