中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (10): 588-590.doi: 10.12144/zgmfskin202010588

• 论著 • 上一篇    下一篇

Spitz痣与恶性黑素瘤患者临床特点及P16表达的分析

王双双,章宜芬,高丽丽,李惠,赵苏苏   

  1. 南京中医药大学附属医院/江苏省中医院病理科，南京，210029
  • 出版日期:2020-10-15 发布日期:2020-09-22
  • 通讯作者: 赵苏苏，E-mail: susu001135@163.com

Clinic features and P16 expression level in the patients with Spitz nevus or malignant melanoma

WANG Shuangshuang, ZHANG Yifen, GAO Lili, LI Hui, ZHAO Susu   

  1. Department of Pathology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
  • Online:2020-10-15 Published:2020-09-22
  • Contact: ZHAO Susu, E-mail: susu001135@163.com

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摘要： 回顾性分析我院2016-2018年确诊的7例Spitz痣和5例恶性黑素瘤患者资料。 Spitz痣患者中男2例，女5例，年龄9～36岁，中位年龄 29岁，发生部位：上肢2例，手部1例，膝部1例，右耳1例，小腿1例，鼻根部1例；5例恶性黑素瘤患者中男1例，女4例，年龄50～84岁，中位年龄78岁，发生部位：足底4例，下肢1例。在7例Spitz痣中P16弥漫性高表达5例，中等表达1例，低表达1例；5例恶性黑素瘤中，P16阴性3例，低表达2例。

关键词: Spitz痣, 免疫组化, P16, 恶性黑色素瘤

Abstract: The data of 7 patients with Spitz nevus and 5 with malignant melanoma diagnosed from 2016 to 2018 was analyzed. Of 7 Spitz nevus patients, 2 were males and 5 were females. The age ranged from 9 to 36 years old with a median age of 29. The lesions were located on the upper limb in 2 patients, on the hand in 1, on the knee in 1, on the right ear in 1, on the lower leg in 1 and on the nose root in 1. Of 5 malignant melanoma patients, 1 were males and 4 were females, the age ranged from 50 to 84 years old with median age of 78 years and the lesion was on the sole of feet in 4, on the lower limb in 1. Of the 7 Spitz nevus patients, P16 was highly expressed in 5 cases, moderately expressed in 1 and lowly expressed in 1. Of the 5 cases of malignant melanoma, P16 was negative in 3 and was lowly expressed in 2.

Key words: Spitz nevus, immunochemistry, P16, melanoma