中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (11): 697-700.doi: 10.12144/zgmfskin202011697

• 综述 • 上一篇    下一篇

EGFR通路在相关皮肤病发病机制中的研究进展

王雯竹1,何艳艳1,2,徐浩翔1   

  1. 1中国医学科学院&北京协和医学院皮肤病医院(研究所)，南京，210042；2江苏省皮肤性病学分子生物学重点实验室，南京，210042
  • 出版日期:2020-11-15 发布日期:2020-11-02
  • 通讯作者: 何艳艳，E-mail: heyanyan.jsnj@163.com；徐浩翔，E-mail: xbpipi@163.com

Update of epidermal growth factor receptor signaling pathway in the pathogenesis of related skin diseases

WANG Wenzhu1, HE Yanyan1,2, XU Haoxiang1   

  1. 1 Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing 210042, China; 2 Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China
  • Online:2020-11-15 Published:2020-11-02
  • Contact: HE Yanyan, E-mail: heyanyan.jsnj@163.com; XU Haoxiang, E-mail: xbpipi@163.com

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摘要： 表皮生长因子受体（EGFR）是一种受体酪氨酸激酶，存在于几乎所有上皮细胞和多种间充质细胞的细胞膜上，EGFR通路的失调可能导致细胞增殖、血管生成、细胞凋亡受损、细胞侵袭性增强，影响银屑病、特应性皮炎等炎症性皮肤病和皮肤鳞状细胞癌、黑素瘤等肿瘤性皮肤病的发生与发展，本文综述了EGFR通路在相关皮肤病发病机制中的研究进展。

关键词: 表皮生长因子受体, 丝裂原活化蛋白激酶, 磷脂酰肌醇3-激酶

Abstract: Epidermal growth factor receptor (EGFR) is one kind of receptor tyrosine kinase, which exists in the membrane of almost all epithelial cells and many mesenchymal cells. The imbalance of EGFR pathway may lead to cell proliferation, angiogenesis, apoptosis damage, cell invasion enhancement, and participate in the pathogenesis of skin inflammation and skin tumor. The update of EGFR pathway in the pathogenesis of related skin diseases is reviewed in this paper.

Key words: epidermal growth factor receptor, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)