中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (2): 116-120.doi: 10.12144/zgmfskin202102116

• 综述 • 上一篇    下一篇

疱疹样皮炎研究进展

房小凯1,2,刘红2,张福仁2   

  1. 1山东大学，山东济南，250012；2山东第一医科大学附属皮肤病医院(山东省皮肤病医院，山东省皮肤病性病防治研究所)，济南，250022
  • 出版日期:2021-02-15 发布日期:2021-02-03
  • 通讯作者: 张福仁，E-mail: zhangfuren@hotmail.com

Update of dermatitis herpetiformis

FANG Xiaokai1,2, LIU Hong2, ZHANG Furen2   

  1. 1 Shandong University, Jinan 250012, China; 2 Shandong Provincial Hospital for Skin Disease & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Jinan 250022,China
  • Online:2021-02-15 Published:2021-02-03
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 疱疹样皮炎(dermatitis herpetiformis, DH)是一种与乳糜泻密切相关的自身免疫性大疱性皮肤病，多见于高加索人群，亚洲人群少见。遗传学研究发现高加索人DH的遗传风险因子为HLA-DQ2和HLA-DQ8，已纳入诊断标准，国人DH风险因子为HLA-B*0801和HLA-DRB1*0301，尚未纳入诊断标准。DH的诱因为麦胶饮食，自身抗原为表皮型谷氨酰胺转移酶，患者体内同时还有抗组织型谷氨酰胺转移酶抗体等。氨苯砜仍然是治疗DH的首选药物。本文将从流行病学、病因、发病机制等方面综述DH的研究进展。

关键词: 疱疹样皮炎, 乳糜泻, 麦胶敏感, 表皮型谷氨酰胺转移酶, 肠道菌群

Abstract: Dermatitis herpetiformis (DH) is an autoimmune bullous skin disease closely related to celiac disease, which is mainly prevalent in Caucasian populations, and rare in Asian population. Genetic studies have found that the genetic risk factors of DH in Caucasians are HLA-DQ2 and HLA-DQ8, which have been included in the diagnostic criteria. DH risk factors in Chinese are HLA-B*0801 and HLA-DRB1*0301, which have not been included in the diagnostic criteria. DH is mainly caused by gluten intake. The epidermal transglutaminase is autoantigen, and the tissue transglutaminase antibody can be positive. The effective treatment for DH is dapsone. The update of DH is summarized including epidemiology, etiology, pathogenesis and so on in this paper.

Key words: dermatitis herpetiformis, celiac disease, gluten sensitivity, epidermal transglutaminase, gut microbiota