中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (7): 451-453.doi: 10.12144/zgmfskin202107451

• 病例报告 • 上一篇    下一篇

盐酸米诺环素联合外用糖皮质激素治疗疱疹样天疱疮一例

冯晓然,李萌萌,黎静宜,薛丽   

  1. 四川大学华西医院皮肤性病科，四川成都,610041
  • 出版日期:2021-07-15 发布日期:2021-06-25
  • 通讯作者: 黎静宜，E-mail: ljy7733@163.com

Minocycline hydrochloride combined with glucocorticoid in the treatment of herpetiform pemphigus: a case report

FENG Xiaoran, LI Mengmeng, LI Jingyi, XUE Li   

  1. Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu 610041, China
  • Online:2021-07-15 Published:2021-06-25
  • Contact: LI Jingyi, E-mail: ljy7733@163.com

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摘要： 患者，男，54岁。全身皮肤红斑、水疱伴瘙痒40天。皮肤组织病理示：表皮棘层中上部水疱，疱内大量嗜酸粒细胞，基底层上方裂隙形成。直接免疫荧光：角质形成细胞间IgG（+），C3（+）,诊断为疱疹样天疱疮。予盐酸米诺环素、复方甘草酸苷片、卤米松/三氯生乳膏、倍他米松尿素霜等治疗。7天后原有水疱干涸，好转出院。

关键词: 疱疹样天疱疮, 盐酸米诺环素

Abstract: A 54-year-old male presented with general erythema, blisters and itching for more than 40 days. Histological examination showed eosinophilic spongiosis with the formation of intraepidermal vesicles. Direct immunofluorescence showed the deposition of IgG and C3 on the cell surfaces of keratinocytes. The diagnosis of herpetiform pemphigus was made. He was treated with oral minocycline hydrochloride and compound glycyrrhizin tablets, topical halometasone/triclosan cream and betamethasone urea cream. The blisters subsided after treatment for 7 days and the patient discharged.

Key words: herpetiform pemphigus, minocycline hydrochloride