中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (12): 772-774.doi: 10.12144/zgmfskin202112772

• 临床研究 • 上一篇    下一篇

首次命名淀粉样变型类天疱疮并附一例报道

孙菲菲,刘红,周桂芝,刘永霞,施仲香,张福仁   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2021-12-15 发布日期:2021-09-29
  • 通讯作者: 施仲香，E-mail: szxsd2003@sina.com；张福仁，E-mail: zhangfuren@hotmail.com

Amyloidosis pemphigoid: a case report

SUN Feifei, LIU Hong, ZHOU Guizhi, LIU Yongxia, SHI Zhongxiang, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2021-12-15 Published:2021-09-29
  • Contact: SHI Zhongxiang, E-mail: szxsd2003@sina.com; ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 本文首次提出淀粉样变型类天疱疮的概念，并报道一例。患者中年女性，躯干、四肢苔藓样皮疹伴瘙痒17年，无水疱。组织病理示：真皮乳头大量嗜酸性无定形物质沉积，结晶紫染色：阳性；DIF：真皮乳头及基底膜IgG、IgM颗粒状沉积，C3、IgA阴性；IIF：类天疱疮循环抗体IgG 1∶320阳性。人皮肤盐裂IIF：循环抗体IgG表皮侧阳性；抗BP180抗体0 U/mL，抗BP230抗体169.2 U/mL。

关键词: 淀粉样变型类天疱疮, 无水疱类天疱疮, 免疫荧光

Abstract: We first proposed the conception of cutaneous amyloidosis pemphigoid and reported a case in this paper. A middle-aged female presented with hypertrophic patches, no blisters, with itching for 17 years on trunk and limbs. Biopsy showed a large number of eosinophilic amorphous substance deposition in dermal papilla and the crystal violet staining was positive. DIF showed the granular deposition of IgG and IgM was found in the basement membrane and dermal papilla, and negitive for C3 and IgA. IIF positivity of antibody IgG was noted with both routine and salt split method. Enzyme-linked immunosorbent assays showed anti BP180 antibody was 0 U/mL and anti BP230 antibody was 169.2 U/mL. 

Key words: amyloidosis pemphigoid, nonbullous pemphigoid, immune fluorescent